Liaoning Province is an important force in China’s biopharmaceutical industry, yet faces the contradiction of "strong basic research and weak industrial transformation." There is an urgent need to innovate new models and establish a full chain from "concept validation to pilot-scale maturation and industrial application." During the concept validation phase, we should develop efficient screening mechanisms aligned with industrial demands and build iterative big data platforms for feedback; the pilot-scale phase requires establishing shared service platforms across three tiers; and in the industrialization stage, a three-tier institutional system integrating "concept validation, pilot-scale support, and industrial empowerment" should be constructed to  stimulate the chain engine for technology transformation and promote the high-quality development of the biopharmaceutical industry in Liaoning Province.

"> biopharmaceutical in Liaoning Province, proof of concept, pilot-scale maturation, industrialization, full chain

辽宁省是我国生物医药产业的重要力量，但是存在着“基础研究强-产业转化弱”的矛盾。亟需创新科技成果转化的新模式，打通“概念验证-中试熟化-产业化”的全链条。概念验证阶段构建以产业需求为导向的高效筛选机制和建设反馈迭代大数据平台；中试阶段实现三级服务平台共享；产业化阶段构建“概念验证-中试保障-产业赋能”三层制度体系来激发科技成果转化的链式引擎，促进辽宁省生物医药产业的高质量发展。