To cultivate pharmacy service-oriented professionals who possess both medical and pharmaceutical expertise, optimizing the construction of core courses in clinical pharmacy and enhancing students’ practical abilities are of utmost importance. Taking the diagnostics on-line and off-line blended first-class course at Shenyang Pharmaceutical University as an example, we have utilized high-quality online resources that complement offline teaching and conducted multiple cycles of teaching practice to improve the content design, the process of organization and implementation, the reform of teaching methods and assessment methods as well as the evaluation of teaching effect. Finally, we constructed core courses suitable for the educational goal of clinical pharmacy specialty. The new teaching mode enhances students' practical ability, improves their learning experience, and achieves good teaching effect. In the meanwhile, it provides a reference for the construction of core undergraduate courses in clinical pharmacy in China.

diagnostics, first-class undergraduate course, on-line and off-line blended teaching, undergraduate teaching reform, clinical pharmacy

为培养懂医精药的药学服务型人才，如何优化临床药学专业核心课程的建设、提高本专业学生的实践能力尤为重要。以沈阳药科大学线上线下混合式一流课程诊断学为例，利用与线下教学相辅相成的线上优质教学资源，通过多个周期的教学实践，完善课程内容设计、组织实施过程、教学方法和成绩评定方式改革以及教学效果评价，构建了适用于临床药学专业育人目标的核心课程。这种新的教学模式提高了学生的实践能力，改善了学生的学习体验，达到了良好的教学效果，为我国临床药学专业本科核心课程建设提供了参考。