Liaoning Province is an important force in China’s biopharmaceutical industry, yet faces the contradiction of "strong basic research and weak industrial transformation." There is an urgent need to innovate new models and establish a full chain from "concept validation to pilot-scale maturation and industrial application." During the concept validation phase, we should develop efficient screening mechanisms aligned with industrial demands and build iterative big data platforms for feedback; the pilot-scale phase requires establishing shared service platforms across three tiers; and in the industrialization stage, a three-tier institutional system integrating "concept validation, pilot-scale support, and industrial empowerment" should be constructed to  stimulate the chain engine for technology transformation and promote the high-quality development of the biopharmaceutical industry in Liaoning Province.

"> biopharmaceutical in Liaoning Province, proof of concept, pilot-scale maturation, industrialization, full chain