Pathophysiology is a highly comprehensive basic medical course that primarily studies the functional and metabolic changes and mechanisms in diseased organisms, serving as a bridge between basic medicine and clinical medicine. However, pharmacy students generally  underestimate its importance. Combined with inadequate background knowledge, the content of the course is dull and difficult to memorize, resulting in limited teaching effectiveness. This discipline investigates the mechanisms of disease development, and its research findings can provide targets for new drug development while laying a solid foundation for in-depth learning of drug mechanisms. Teachers should guide pharmacy students to reflect on the significance of studying pathophysiology in their professional training, which will help enhance their learning initiative. Additionally, teachers in pharmaceutical colleges and universities can introduce case-based teaching in combination with the characteristics of their pharmaceutical disciplines. By utilizing extensive online resources and sharing medical knowledge videos, they can foster students’ interest in learning, keep them abreast of medical advancements, and ultimately improve the teaching effectiveness of pathophysiology.